TY - GEN AU - Martín-Serrano, Ángela AU - Gonzalez-Morena, Juan M. AU - Barbero, Nekane AU - Ariza, Adriana AU - Sánchez Gómez, Francisco J. AU - Pérez-Inestrosa, Ezequiel AU - Pérez-Sala, Dolores AU - Torres, Maria J. AU - Montañez, María I. PY - 2020 DO - 10.3389/fphar.2020.594755 UR - http://hdl.handle.net/20.500.12105/18154 AB - Clavulanic acid (CLV) and amoxicillin, frequently administered in combination, can be independently involved in allergic reactions. Protein haptenation with β-lactams is considered necessary to activate the immune system. The aim of this study was to... LA - eng PB - Frontiers Media KW - Betalactam KW - Biotin tag KW - Biotinylation KW - Clavulanate KW - Drug allergy KW - Haptenation KW - Beta-lactamas KW - Biotina KW - Ácido clavulánico KW - Hipersensibilidad a las drogas KW - beta-Lactams KW - Biotinylation KW - Clavulanic Acid KW - Drug Hypersensitivity KW - Biotin KW - Humans KW - Mass Spectrometry KW - Immune System KW - Immunoproteins KW - Peptides KW - Avidin KW - Haptoglobins KW - Solubility TI - Biotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies TY - research article ER -