TY - JOUR AU - de Carcer Diez, Guillermo AU - Venkateswaran, Sharavan Vishaan AU - Salgueiro, Lorena AU - El Bakkali, Aicha AU - Somogyi, Kalman AU - Rowald, Konstantina AU - Montañés, Pablo AU - Sanclemente, Manuel AU - Escobar, Beatriz AU - de Martino, Alba AU - McGranahan, Nicholas AU - Malumbres Martinez, Marcos AU - Sotillo, Rocío PY - 2018 DO - 10.1038/s41467-018-05429-5 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/6546 AB - Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene and an attractive cancer target. However, its contribution to tumor development is unclear. Using a new inducible knock-in mouse... LA - eng PB - Nature Publishing Group KW - POLO-LIKE KINASE KW - BREAST-CANCER KW - THERAPEUTIC TARGETS KW - ANTICANCER THERAPY KW - MAMMALIAN-CELLS KW - ESCRT MACHINERY KW - SCREEN KW - ANEUPLOIDY KW - EXPRESSION KW - MICE TI - Plk1 overexpression induces chromosomal instability and suppresses tumor development TY - journal article ER -