TY - GEN AU - Garcia, Maria Teresa AU - Carreño, David AU - Tirado-Velez, JM AU - Ferrandiz-Avellano, Maria-Jose AU - Rodrigues, Liliana AU - Gracia, Begoña AU - Amblar, Monica AU - Ainsa, José A AU - de la Campa, Adela G PY - 2018 DO - 10.3389/fmicb.2018.01659 SN - 1664-302X UR - http://hdl.handle.net/20.500.12105/9121 AB - The spread of multidrug-resistant isolates of Mycobacterium tuberculosis requires the discovery of new drugs directed to new targets. In this study, we investigated the activity of two boldine-derived alkaloids, seconeolitsine (SCN) and... LA - eng PB - Frontiers Media KW - DNA supercoiling KW - DNA topoisomerase I inhibitor KW - Mycobacterium tuberculosis KW - N-methyl-seconeolitsine KW - Antituberculosis activity KW - Drug discovery KW - Seconeolitsine TI - Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis TY - research article ER -