TY - JOUR AU - Kondoh, Hiroshi AU - Lleonart, Matilde E AU - Gil, Jesús AU - Wang, Jing AU - Degan, Paolo AU - Peters, Gordon AU - Martinez Garcia, Maria Dolores AU - Carnero, Amancio AU - Beach, David PY - 2005 DO - 10.1158/0008-5472.177.65.1 SN - 0008-5472 UR - http://hdl.handle.net/20.500.12105/17406 AB - An unbiased screen for genes that can immortalize mouse embryonic fibroblasts identified the glycolytic enzyme phosphoglycerate mutase (PGM). A 2-fold increase in PGM activity enhances glycolytic flux, allows indefinite proliferation, and renders... LA - eng PB - American Association for Cancer Research (AACR) KW - Glycolysis KW - Animals KW - Cell Division KW - Cell Survival KW - Cells, Cultured KW - Embryo, Mammalian KW - Fibroblasts KW - Genes, ras KW - Mice KW - Mice, Inbred C57BL KW - Phosphoglycerate Mutase TI - Glycolytic enzymes can modulate cellular life span. TY - journal article ER -