TY - GEN AU - Rico-Llanos, Gustavo AU - Porras-Perales, Óscar AU - Escalante, Sandra AU - Vázquez-Calero, Daniel B AU - Valiente, Lucía AU - Castillo, María I AU - Pérez-Tejeiro, José Miguel AU - Baglietto-Vargas, David AU - Becerra, José AU - Reguera, José María AU - Duran, Ivan AU - Csukasi, Fabiana PY - 2022 DO - 10.3389/fimmu.2022.1054962 UR - http://hdl.handle.net/20.500.12105/18855 AB - Inflammation is a central pathogenic feature of the acute respiratory distress syndrome (ARDS) in COVID-19. Previous pathologies such as diabetes, autoimmune or cardiovascular diseases become risk factors for the severe hyperinflammatory syndrome. A... LA - eng KW - 4-PBA KW - COVID-19 KW - TNFa KW - acute respiratory distress syndrome KW - binding-immunoglobulinprotein (BiP/GRP78/HSPA5) KW - cell surface GRP78 (csGRP78) KW - cellular stress KW - cytokine storm KW - Humans KW - COVID-19 KW - SARS-CoV-2 KW - Respiratory Distress Syndrome KW - Inflammation KW - Endoplasmic Reticulum Chaperone BiP KW - Lung TI - Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP. TY - research article ER -