TY  - GEN
AU  - Jutzi, Jonas S
AU  - Marneth, Anna E
AU  - Ciboddo, Michele
AU  - Guerra-Moreno, Angel
AU  - Jiménez-Santos, María José
AU  - Kosmidou, Anastasia
AU  - Dressman, James W
AU  - Liang, Hongyan
AU  - Hamel, Rebecca
AU  - Lozano, Patricia
AU  - Rumi, Elisa
AU  - Doench, John G
AU  - Gotlib, Jason
AU  - Krishnan, Anandi
AU  - Elf, Shannon
AU  - Al-Shahrour, Fatima
AU  - Mullally, Ann
PY  - 2022
DO  - 10.1182/blood.2022015629
UR  - http://hdl.handle.net/20.500.12105/19755
AB  - Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by which CALR mutations cause MPNs has been elucidated, there currently are no clonally selective therapies...
LA  - eng
PB  - American Society of Hematology (ASH)
KW  - Calreticulin
KW  - Myeloproliferative Disorders
KW  - Animals
KW  - Clustered Regularly Interspaced Short Palindromic Repeats
KW  - Glucose
KW  - Glycosylation
KW  - Humans
KW  - Janus Kinase 2
KW  - Mice
KW  - Mutation
KW  - Receptors, Thrombopoietin
TI  - Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs.
TY  - other
ER  -