TY  - JOUR
AU  - Toledo, Luis I
AU  - Murga, Matilde
AU  - Zur, Rafal
AU  - Soria, Rebeca
AU  - Rodriguez, Antonio
AU  - Martinez, Sonia
AU  - Oyarzabal, Julen
AU  - Pastor, Joaquin
AU  - Bischoff, James R
AU  - Fernandez-Capetillo, Oscar
PY  - 2011
DO  - 10.1038/nsmb.2076
UR  - http://hdl.handle.net/20.500.12105/17684
AB  - Oncogene activation has been shown to generate replication-born DNA damage, also known as replicative stress. The primary responder to replicative stress is not Ataxia-Telangiectasia Mutated (ATM) but rather the kinase ATM and Rad3-related (ATR). One...
LA  - eng
PB  - Nature Publishing Group
KW  - Animals
KW  - Antineoplastic Agents
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - Cell Cycle Proteins
KW  - Cell Survival
KW  - Cells, Cultured
KW  - Chromosome Breakage
KW  - Drug Screening Assays, Antitumor
KW  - Enzyme Inhibitors
KW  - Fibroblasts
KW  - Imidazoles
KW  - Mice
KW  - Oxazines
KW  - Protein Serine-Threonine Kinases
KW  - Quinolines
KW  - Tumor Suppressor Protein p53
TI  - A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.
TY  - journal article
ER  -