TY - JOUR AU - Molina-Sanchez, Pedro AU - Chevre, Raphael AU - Rius, Cristina AU - Fuster, Jose J. AU - Andres, Vicente PY - 2015 DO - 10.1016/j.yjmcc.2015.04.013 SN - 00222828 UR - http://hdl.handle.net/20.500.12105/7924 AB - Reduced phosphorylation of the tumor suppressor p27(Kip1) (p27) at serine 10 (Ser10) is a hallmark of advanced human and mouse atherosclerosis. Apolipoprotein E-null mice defective for this posttranslational modification (apoE(-/-)p27Ser10Ala)... LA - eng PB - Elsevier KW - Atherosclerosis KW - Endothelial cell KW - Leukocyte recruitment KW - RhoA KW - p27 KW - Animals KW - Aorta KW - Apolipoproteins E KW - Arterioles KW - Atherosclerosis KW - Cell Adhesion KW - Cells, Cultured KW - Cyclin-Dependent Kinase Inhibitor p27 KW - Diet KW - Endothelial Cells KW - Enzyme Activation KW - Hypercholesterolemia KW - Leukocytes KW - Mice, Inbred C57BL KW - Phosphorylation KW - Phosphoserine KW - Plaque, Atherosclerotic KW - Signal Transduction KW - Vascular Cell Adhesion Molecule-1 KW - rho-Associated Kinases KW - rhoA GTP-Binding Protein TI - Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK TY - journal article ER -