TY  - GEN
AU  - Mutz, Cornelia N
AU  - Schwentner, Raphaela
AU  - Kauer, Maximilian O
AU  - Katschnig, Anna M
AU  - Kromp, Florian
AU  - Aryee, Dave N T
AU  - Erhardt, Sophie
AU  - Goiny, Michel
AU  - Alonso, Javier
AU  - Fuchs, Dietmar
AU  - Kovar, Heinrich
PY  - 2016
DO  - 10.1002/1873-3468.12243
UR  - http://hdl.handle.net/20.500.12105/13225
AB  - Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS-FLI1. We report that EWS-FLI1 suppresses TDO2-mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS-FLI1-dependent...
LA  - eng
PB  - Wiley
KW  - EWS-FLI1
KW  - Aryl hydrocarbon receptor
KW  - Tryptophan
KW  - Autocrine Communication
KW  - Signal Transduction
KW  - Cell Line
KW  - Humans
KW  - Kynurenine
KW  - Oncogene Proteins, Fusion
KW  - Proto-Oncogene Protein c-fli-1
KW  - RNA-Binding Protein EWS
KW  - Receptors, Aryl Hydrocarbon
KW  - Tryptophan
KW  - Tryptophan Oxygenase
TI  - EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway
TY  - research article
ER  -