TY - GEN AU - Sherzai, Mursal AU - Valle, Adamo AU - Perry, Nicholas AU - Kalef-Ezra, Ester AU - Al-Mahdawi, Sahar AU - Pook, Mark AU - Virmouni, Sara Anjomani PY - 2020 DO - 10.3389/fgene.2020.00584 UR - https://hdl.handle.net/20.500.12105/22919 AB - Friedreich's ataxia (FRDA) is a progressive neurodegenerative disorder caused by a homozygous GAA repeat expansion mutation in intron 1 of the frataxin gene (FXN), which instigates reduced transcription. As a consequence, reduced levels of frataxin... LA - eng PB - Frontiers Media KW - FRDA KW - Friedreich ataxia KW - Frataxin KW - FXN KW - GAA repeat KW - HMTase inhibitor TI - HMTase Inhibitors as a Potential Epigenetic-Based Therapeutic Approach for Friedreich's Ataxia TY - research article ER -