TY - JOUR AU - Rodriguez Antona, Cristina AU - Niemi, M AU - Backman, J T AU - Kajosaari, L I AU - Neuvonen, P J AU - Robledo Batanero, Mercedes AU - Ingelman-Sundberg, M PY - 2008 DO - 10.1038/sj.tpj.6500482 UR - http://hdl.handle.net/20.500.12105/17495 AB - Cytochrome P450 2C8 (CYP2C8) plays a major role in the metabolism of therapeutically important drugs which exhibit large interindividual differences in their pharmacokinetics. In order to evaluate any genetic influence on this variation, a CYP2C8... LA - eng PB - Nature Publishing Group KW - Aryl Hydrocarbon Hydroxylases KW - Carbamates KW - Cytochrome P-450 CYP2C8 KW - Genetic Variation KW - Haplotypes KW - Humans KW - Paclitaxel KW - Piperidines KW - White People TI - Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism. TY - journal article ER -