TY - JOUR AU - Martínez-Bonet, Marta AU - Palladino, Claudia AU - Briz, Veronica AU - Rudolph, Jochen M AU - Fackler, Oliver T AU - Relloso, Miguel AU - Muñoz-Fernandez, Maria Angeles AU - Madrid, Ricardo PY - 2015 DO - 10.1371/journal.pone.0145239 UR - http://hdl.handle.net/20.500.12105/12749 AB - To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef. We identified the GPG-motif, located at the 121-137 region of HIV-1 NL4.3... LA - eng PB - Public Library of Science (PLOS) KW - Amino Acid Motifs KW - HIV-1 KW - HeLa Cells KW - Humans KW - Protein Structure, Tertiary KW - Structure-Activity Relationship KW - T-Lymphocytes KW - nef Gene Products, Human Immunodeficiency Virus TI - A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. TY - journal article ER -