TY - JOUR AU - Aguirre, Luis A. AU - Alonso, M. Eva AU - Badia-Careaga, Claudio AU - Rollan, Isabel AU - Arias, Cristina AU - Fernandez-Minan, Ana AU - Lopez-Jimenez, Elena AU - Aranega, Amelia AU - Gomez-Skarmeta, Jose Luis AU - Franco, Diego AU - Manzanares, Miguel PY - 2015 DO - 10.1186/s12915-015-0138-0 SN - 1741-7007 UR - http://hdl.handle.net/20.500.12105/5408 AB - Background: Recent genome-wide association studies have uncovered genomic loci that underlie an increased risk for atrial fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a gene desert at 4q25,... LA - eng PB - BioMed Central (BMC) KW - Atrial fibrillation KW - Chromosome conformation KW - ENPEP KW - PITX2 KW - Regulatoryelement KW - GENOME-WIDE ASSOCIATION KW - LEFT-RIGHT ASYMMETRY KW - TRANSPOSABLE ELEMENTS KW - AMINOPEPTIDASE-A KW - CHROMOSOME 4Q25 KW - COMMON VARIANTS KW - GENE-EXPRESSION KW - HUMAN ENHANCERS KW - DNA ELEMENTS KW - HEART TI - Long-range regulatory interactions at the 4q25 atrial fibrillation risklocus involve PITX2c and ENPEP TY - journal article ER -