TY - JOUR AU - Wachowicz, Paulina AU - Fernandez-Miranda, Gonzalo AU - Marugan, Carlos AU - Escobar, Beatriz AU - de Carcer, Guillermo PY - 2016 DO - 10.1002/bies.201670908 SN - 0265-9247 UR - http://hdl.handle.net/20.500.12105/5212 AB - Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays multiple and essential roles during the cell division cycle. Its inhibition in cultured cells leads to severe mitotic aberrancies and cell death. Whereas previous reports suggested that... LA - eng PB - Wiley KW - cell cycle KW - development KW - mitosis KW - Polo-like kinase 1 KW - spindle dynamics KW - CELL-CYCLE KW - PROTEIN-KINASE KW - BOX DOMAIN KW - SACCHAROMYCES-CEREVISIAE KW - CHROMOSOME SEGREGATION KW - MAMMALIAN-CELLS KW - DROSOPHILA POLO KW - CENTROSOMAL LOCALIZATION KW - TUMOR SUPPRESSION KW - CANCER-THERAPY TI - Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies TY - journal article ER -