TY - JOUR AU - Papaspyridonos, Marianna AU - Matei, Irina AU - Huang, Yujie AU - do Rosario Andre, Maria AU - Brazier-Mitouart, Helene AU - Waite, Janelle C AU - Chan, April S AU - Kalter, Julie AU - Ramos, Ilyssa AU - Wu, Qi AU - Williams, Caitlin AU - Wolchok, Jedd D AU - Chapman, Paul B AU - Peinado Selgas, Hector AU - Anandasabapathy, Niroshana AU - Ocean, Allyson J AU - Kaplan, Rosandra N AU - Greenfield, Jeffrey P AU - Bromberg, Jacqueline AU - Skokos, Dimitris AU - Lyden, David PY - 2015 DO - 10.1038/ncomms7840 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/10087 AB - A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1... LA - eng PB - Nature Publishing Group KW - Animals KW - Cell Differentiation KW - Disease Progression KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Inhibitor of Differentiation Protein 1 KW - Interferon Regulatory Factors KW - Leukocytes, Mononuclear KW - Melanoma, Experimental KW - Mice, Inbred C57BL KW - Myeloid Cells KW - Neoplasm Metastasis KW - Transforming Growth Factor beta TI - Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation TY - journal article ER -