TY  - JOUR
AU  - Martinez-Lage, M
AU  - Raul, Torres-Ruiz
AU  - Puig-Serra, P
AU  - Moreno-Gaona, P
AU  - Martin, M C
AU  - Moya, F J
AU  - Quintana-Bustamante, O
AU  - Garcia-Silva, S
AU  - Carcaboso, A M
AU  - Petazzi, P
AU  - Bueno, C
AU  - Mora, J
AU  - Peinado, H
AU  - Segovia, J C
AU  - Menendez, P
AU  - Rodriguez Perales, Sandra
PY  - 2020
DO  - 10.1038/s41467-020-18875-x
UR  - http://hdl.handle.net/20.500.12105/12176
AB  - Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of tumor development. Because their expression is exclusive to cancer cells and their elimination induces cell apoptosis in FO-driven cancers, FOs are attractive...
LA  - eng
PB  - Nature Publishing Group
KW  - Animals
KW  - Base Sequence
KW  - CRISPR-Cas Systems
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Doxorubicin
KW  - Fusion Proteins, bcr-abl
KW  - Gene Deletion
KW  - Genetic Loci
KW  - Genomic Instability
KW  - HEK293 Cells
KW  - Humans
KW  - Introns
KW  - Mice, Nude
KW  - Neoplasms
KW  - Oncogene Fusion
KW  - Oncogene Proteins, Fusion
KW  - RNA, Guide
KW  - Reproducibility of Results
KW  - Xenograft Model Antitumor Assays
TI  - In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells.
TY  - journal article
ER  -