TY - JOUR AU - Fraga, Mario F AU - Herranz, Michel AU - Espada, Jesús AU - Ballestar, Esteban AU - Paz, Maria F AU - Ropero, Santiago AU - Erkek, Emel AU - Bozdogan, Onder AU - Peinado, Héctor AU - Niveleau, Alain AU - Mao, Jian-Hua AU - Balmain, Alan AU - Cano, Amparo AU - Esteller, Manel PY - 2004 DO - 10.1158/0008-5472.CAN-03-4061 SN - 0008-5472 UR - http://hdl.handle.net/20.500.12105/17964 AB - Whereas accepted models of tumorigenesis exist for genetic lesions, the timing of epigenetic alterations in cancer is not clearly understood. We have analyzed the profile of aberrations in DNA methylation occurring in cells lines and primary tumors of... LA - eng PB - American Association for Cancer Research (AACR) KW - DNA Methylation KW - 5-Methylcytosine KW - Animals KW - Cell Line, Tumor KW - DNA Modification Methylases KW - DNA, Neoplasm KW - Gene Expression Regulation, Neoplastic KW - Gene Silencing KW - Genes, Tumor Suppressor KW - Histones KW - Humans KW - Insulin-Like Growth Factor Binding Protein 3 KW - LIM Domain Proteins KW - Mice KW - Muscle Proteins KW - Nuclear Proteins KW - Oligonucleotide Array Sequence Analysis KW - Skin Neoplasms TI - A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. TY - journal article ER -