TY  - JOUR
AU  - Apellániz-Ruiz, M
AU  - Inglada-Pérez, L
AU  - Naranjo, M E G
AU  - Sánchez, L
AU  - Mancikova, V
AU  - Currás-Freixes, M
AU  - de Cubas, A A
AU  - Comino-Méndez, I
AU  - Triki, S
AU  - Rebai, A
AU  - Rasool, M
AU  - Moya, G
AU  - Grazina, M
AU  - Opocher, G
AU  - Cascón, A
AU  - Taboada-Echalar, P
AU  - Ingelman-Sundberg, M
AU  - Carracedo, A
AU  - Robledo Batanero, Mercedes
AU  - Llerena, A
AU  - Rodriguez Antona, Cristina
PY  - 2015
DO  - 10.1038/tpj.2014.67
UR  - http://hdl.handle.net/20.500.12105/17505
AB  - Cytochrome P450 3A4 (CYP3A4) is a key drug-metabolizing enzyme. Loss-of-function variants have been reported as rare events, and the first demonstration of a CYP3A4 protein lacking functional activity is caused by CYP3A4*20 allele. Here we...
LA  - eng
PB  - Nature Publishing Group
KW  - Alleles
KW  - Cytochrome P-450 CYP3A
TI  - High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme.
TY  - journal article
ER  -