TY - GEN AU - Zarich-Dimitrievich, Natasha AU - Oliva-Martinez, Jose Luis AU - Martinez, Natalia AU - Jorge, Rocío AU - Ballester, Alicia AU - Gutiérrez-Eisman, Silvia AU - Garcia-Vargas, Susana AU - Rojas-Cabañeros, Jose Maria PY - 2006 DO - 10.1091/mbc.e05-12-1104 SN - 1059-1524 UR - https://hdl.handle.net/20.500.12105/26126 AB - hSos1 is a Ras guanine-nucleotide exchange factor. It was suggested that the carboxyl-terminal region of hSos1 down-regulates hSos1 functionality and that the intrinsic guanine-nucleotide exchange activity of this protein may be different before and... LA - eng PB - American Society for Cell Biology (ASCB) KW - Animals KW - COS Cells KW - Cells, Cultured KW - Chlorocebus aethiops KW - Down-Regulation KW - GRB2 Adaptor Protein KW - HeLa Cells KW - Humans KW - Mice KW - Mutant Proteins KW - NIH 3T3 Cells KW - SOS1 Protein TI - Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1 TY - research article ER -