TY  - GEN
AU  - Rodriguez Perales, Sandra
AU  - Torres-Ruiz, Raul
AU  - Suela, J
AU  - Acquadro, F
AU  - Martin, M C
AU  - Yebra, E
AU  - Ramirez, J C
AU  - Alvarez, S
AU  - Cigudosa, J C
PY  - 2016
UR  - https://hdl.handle.net/20.500.12105/26149
AB  - We have identified a new t(1;21)(p32;q22) chromosomal translocation in a MDS/AML patient that results in expression of an aberrant C-terminally truncated RUNX1 protein lacking several regulatory domains. As similar truncated RUNX1 proteins are...
LA  - eng
PB  - Nature
KW  - ACUTE MYELOID-LEUKEMIA
KW  - ACUTE MYELOGENOUS LEUKEMIA
KW  - ACUTE LYMPHOBLASTIC-LEUKEMIA
KW  - INCREASED FLT3 EXPRESSION
KW  - POINT MUTATIONS
KW  - MYELODYSPLASTIC SYNDROME
KW  - STEM-CELLS
KW  - TRANSCRIPTIONAL ACTIVATION
KW  - AML1/PEBP2-ALPHA-B GENE
KW  - ACQUIRED TRISOMY-21
TI  - Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors.
TY  - research article
ER  -