TY - GEN AU - Gómez-Pérez, R AU - Redondo, M AU - Martínez, A AU - Gil, C AU - Gonzalez, Carlos AU - Bravo, Beatriz AU - Ballester, Alicia AU - Eguiluz, Cesar AU - Ballester, Sara PY - 2013 DO - 10.1111/bph.12308 SN - 0007-1188 UR - http://hdl.handle.net/20.500.12105/10630 AB - Background and purpose: PDE4 inhibition suppresses experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). However, side effects hinder PDE4 inhibitors clinical use. PDE7 inhibition might constitute an alternative... LA - eng PB - Wiley KW - Animals KW - Anti-Inflammatory Agents KW - Brain KW - Cells, Cultured KW - Cyclic Nucleotide Phosphodiesterases, Type 4 KW - Cyclic Nucleotide Phosphodiesterases, Type 7 KW - Encephalomyelitis, Autoimmune, Experimental KW - Forkhead Transcription Factors KW - Inflammation Mediators KW - Interleukin-10 KW - Interleukin-17 KW - Interleukins KW - Mice KW - Mice, Inbred C57BL KW - Phosphodiesterase 4 Inhibitors KW - Rolipram KW - Spleen KW - T-Lymphocytes, Regulatory TI - Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis TY - research article ER -