TY - GEN AU - Lonardo, Enza AU - Hermann, Patrick C AU - Mueller, Maria-Theresa AU - Huber, Stephan AU - Balic, Anamaria AU - Miranda-Lorenzo, Irene AU - Zagorac, Sladjana AU - Alcala, Sonia AU - Rodriguez-Arabaolaza, Iker AU - Ramirez, Juan Carlos AU - Torres-Ruiz, Raul AU - Garcia, Elena AU - Hidalgo, Manuel AU - Cebrián, David Álvaro AU - Heuchel, Rainer AU - Löhr, Matthias AU - Berger, Frank AU - Bartenstein, Peter AU - Aicher, Alexandra AU - Heeschen, Christopher PY - 2011 UR - https://hdl.handle.net/20.500.12105/26148 AB - Nodal and Activin belong to the TGF-β superfamily and are important regulators of embryonic stem cell fate. Here we investigated whether Nodal and Activin regulate self-renewal of pancreatic cancer stem cells. Nodal and Activin were hardly detectable... LA - eng PB - Cell Press KW - ACTIVIN-A KW - STELLATE-CELLS KW - TGF-BETA KW - HEDGEHOG PROMOTES KW - GROWTH-FACTOR KW - PATHWAYS KW - INHIBITION KW - PHENOTYPE KW - FIBROSIS KW - AGGRESSIVENESS TI - Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. TY - research article ER -