TY  - JOUR
AU  - Aragoneses-Fenoll, Laura
AU  - Montes-Casado, Maria
AU  - Ojeda, Gloria
AU  - Acosta, Y Y
AU  - Herranz, J
AU  - Martinez, Sonia
AU  - Blanco-Aparicio, Carmen
AU  - Criado, G
AU  - Pastor Fernandez, Joaquin
AU  - Dianzani, U
AU  - Portoles, Pilar
AU  - Rojo, J M
PY  - 2016
DO  - 10.1016/j.bcp.2016.02.005
SN  - 0006-2952
UR  - http://hdl.handle.net/20.500.12105/10246
AB  - Class IA phosphoinositide 3-kinases (PI3Ks) are essential to function of normal and tumor cells, and to modulate immune responses. T lymphocytes express high levels of p110α and p110δ class IA PI3K. Whereas the functioning of PI3K p110δ in immune and...
LA  - eng
PB  - Elsevier
KW  - A-66
KW  - CD28
KW  - ETP-46321
KW  - IC-87114
KW  - ICOS
KW  - PI3K inhibitors
KW  - Phosphatidyl inositol-3 kinase
KW  - Rheumatoid arthritis
KW  - T lymphocytes
KW  - Animals
KW  - Antibodies
KW  - Arthritis, Experimental
KW  - CD28 Antigens
KW  - CD3 Complex
KW  - CD4-Positive T-Lymphocytes
KW  - Class Ia Phosphatidylinositol 3-Kinase
KW  - Enzyme Inhibitors
KW  - Extracellular Signal-Regulated MAP Kinases
KW  - Gene Expression
KW  - Imidazoles
KW  - Interferon-gamma
KW  - Interleukin-10
KW  - Interleukin-2
KW  - Lymph Nodes
KW  - Lymphocyte Activation
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - NFATC Transcription Factors
KW  - Protein Subunits
KW  - Proto-Oncogene Proteins c-akt
KW  - Pyrazines
KW  - T-Box Domain Proteins
KW  - Phosphoinositide-3 Kinase Inhibitors
TI  - ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis
TY  - journal article
ER  -