TY  - JOUR
AU  - Villa-Bellosta, Ricardo
AU  - Rivera-Torres, Jose
AU  - Osorio, Fernando G
AU  - Acin-Perez, Rebeca
AU  - Enriquez, Jose Antonio
AU  - López-Otín, Carlos
AU  - Andres, Vicente
PY  - 2013
DO  - 10.1161/CIRCULATIONAHA.112.000571
SN  - 0009-7322
UR  - http://hdl.handle.net/20.500.12105/7754
AB  - BACKGROUND: Progerin is a mutant form of lamin A responsible for Hutchinson-Gilford progeria syndrome (HGPS), a premature aging disorder characterized by excessive atherosclerosis and vascular calcification that leads to premature death, predominantly...
LA  - eng
KW  - ATP
KW  - Hutchinson-Gilford progeria syndrome
KW  - muscle
KW  - Progerin
KW  - Pyrophosphate
KW  - Tissue-non specific alkaline phosphatase
KW  - Vascular calcification
KW  - Smooth
KW  - Adenosine Triphosphate
KW  - Alkaline Phosphatase
KW  - Animals
KW  - Aorta
KW  - Cells, Cultured
KW  - Diphosphates
KW  - Disease Models, Animal
KW  - Lamin Type A
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Mutant Strains
KW  - Mitochondria, Muscle
KW  - Muscle, Smooth, Vascular
KW  - Progeria
KW  - Treatment Outcome
KW  - Vascular Calcification
TI  - Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment
TY  - journal article
ER  -