TY  - GEN
AU  - Hernandez-Muñoz, Inmaculada
AU  - Figuerola, Elisabeth
AU  - Sanchez-Molina, Sara
AU  - Rodriguez, Eva
AU  - Fernández-Mariño, Ana Isabel
AU  - Pardo-Pastor, Carlos
AU  - Bahamonde, María Isabel
AU  - Fernández-Fernández, José M
AU  - García-Domínguez, Daniel J
AU  - Hontecillas-Prieto, Lourdes
AU  - Lavarino, Cinzia
AU  - Carcaboso, Angel M
AU  - de Torres, Carmen
AU  - Tirado, Oscar M
AU  - de Álava, Enrique
AU  - Mora, Jaume
PY  - 2016
DO  - 10.18632/oncotarget.10092
UR  - https://hdl.handle.net/20.500.12105/25215
AB  - Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate that RING1B is highly expressed in primary ES tumors, and its expression is independent of the fusion oncogene. RING1B-depleted ES...
LA  - eng
KW  - Ewing sarcoma
KW  - FGFR/SHP2/STAT3
KW  - NF-κB
KW  - RING1B
KW  - voltage-gated sodium channel
KW  - Bone Neoplasms
KW  - Humans
KW  - NAV1.6 Voltage-Gated Sodium Channel
KW  - NF-kappa B
KW  - Polycomb Repressive Complex 1
KW  - Sarcoma, Ewing
KW  - Signal Transduction
KW  - Tumor Cells, Cultured
TI  - RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein
TY  - research article
ER  -