TY - GEN AU - Talamillo, A AU - Grande, L AU - Ruiz-Ontañon, P AU - Velasquez, C AU - Mollinedo, P AU - Torices, S AU - Sánchez-Gómez, Pilar AU - Aznar, A AU - Esparis-Ogando, A AU - Lopez-Lopez, C AU - Lafita, C AU - Berciano, M T AU - Montero, J A AU - Vazquez-Barquero, A AU - Segura, V AU - Villagra, N T AU - Pandiella, A AU - Lafarga, Miguel AU - Leon, J AU - Martinez-Climent, J A AU - Sanz-Moreno, V AU - Fernandez-Luna, J L PY - 2016 DO - 10.1038/onc.2016.341 SN - 0950-9232 UR - http://hdl.handle.net/20.500.12105/7897 AB - Long-term survival remains low for most patients with glioblastoma (GBM), which reveals the need for markers of disease outcome and novel therapeutic targets. We describe that ODZ1 (also known as TENM1), a type II transmembrane protein involved in... LA - eng PB - Springer KW - Animals KW - Cell Line, Tumor KW - Disease Models, Animal KW - Gene Knockout Techniques KW - Glioblastoma KW - Heterografts KW - Humans KW - Mice KW - Neoplastic Stem Cells KW - Nerve Tissue Proteins KW - Prognosis KW - Protein Transport KW - Proteolysis KW - Proto-Oncogene Proteins c-myc KW - Signal Transduction KW - Tenascin KW - Up-Regulation KW - rho-Associated Kinases KW - rhoA GTP-Binding Protein KW - Gene Expression Regulation, Neoplastic KW - Transcription, Genetic TI - ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA TY - preprint ER -