TY - JOUR AU - Celeste, Arkady AU - Petersen, Simone AU - Romanienko, Peter J AU - Fernandez-Capetillo, Oscar AU - Chen, Hua Tang AU - Sedelnikova, Olga A AU - Reina-San-Martin, Bernardo AU - Coppola, Vincenzo AU - Meffre, Eric AU - Difilippantonio, Michael J AU - Redon, Christophe AU - Pilch, Duane R AU - Olaru, Alexandru AU - Eckhaus, Michael AU - Camerini-Otero, R Daniel AU - Tessarollo, Lino AU - Livak, Ferenc AU - Manova, Katia AU - Bonner, William M AU - Nussenzweig, Michel C AU - Nussenzweig, André PY - 2002 DO - 10.1126/science.1069398 UR - http://hdl.handle.net/20.500.12105/17702 AB - Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is associated with the recruitment of repair factors to damaged DNA. To help... LA - eng PB - American Association for the Advancement of Science (AAAS) KW - Chromosome Aberrations KW - DNA Repair KW - Recombination, Genetic KW - Amino Acid Sequence KW - Animals KW - B-Lymphocytes KW - Base Sequence KW - Cell Cycle KW - Cells, Cultured KW - Cellular Senescence KW - DNA Damage KW - Female KW - Gene Targeting KW - Histones KW - Immunoglobulin Class Switching KW - Infertility, Male KW - Lymphocyte Count KW - Male KW - Meiosis KW - Mice KW - Mice, Knockout KW - Molecular Sequence Data KW - Mutation KW - Phosphorylation KW - Spermatocytes KW - T-Lymphocytes TI - Genomic instability in mice lacking histone H2AX. TY - journal article ER -