TY - JOUR AU - Marqués, Miriam AU - Tranchant, Robin AU - Risa-Ebrí, Blanca AU - Suárez-Solís, María L AU - Fernández, Luis C AU - Carrillo-de-Santa-Pau, Enrique AU - Del Pozo, Natalia AU - Martínez de Villarreal, Jaime AU - Meiller, Clément AU - Allory, Yves AU - Blum, Yuna AU - Pirker, Christine AU - Hegedus, Balazs AU - Barry, Simon T AU - Carnero, Amancio AU - Berger, Walter AU - Jean, Didier AU - Real Arribas, Francisco PY - 2020 DO - 10.1158/0008-5472.CAN-19-1633 UR - http://hdl.handle.net/20.500.12105/18194 AB - Among malignant mesotheliomas (MM), the sarcomatoid subtype is associated with higher chemoresistance and worst survival. Due to its low incidence, there has been little progress in the knowledge of the molecular mechanisms associated with sarcomatoid... LA - eng PB - American Association for Cancer Research (AACR) KW - Aniline Compounds KW - Animals KW - Antineoplastic Combined Chemotherapy Protocols KW - Benzimidazoles KW - Cell Proliferation KW - Chromones KW - Class I Phosphatidylinositol 3-Kinases KW - Disease Models, Animal KW - Epithelium KW - Female KW - Gene Knock-In Techniques KW - Humans KW - Lung Neoplasms KW - Mesothelioma KW - Mesothelioma, Malignant KW - Mice KW - Mice, Knockout KW - Mitogen-Activated Protein Kinase Kinases KW - Molecular Targeted Therapy KW - PTEN Phosphohydrolase KW - Peritoneal Neoplasms KW - Peritoneum KW - Pleura KW - Pleural Neoplasms KW - Primary Cell Culture KW - Prognosis KW - Protein Kinase Inhibitors KW - Tumor Suppressor Protein p53 TI - Combined MEK and PI3K/p110β Inhibition as a Novel Targeted Therapy for Malignant Mesothelioma Displaying Sarcomatoid Features. TY - journal article ER -