TY  - GEN
AU  - Alvarez, Sara
AU  - Suela, Javier
AU  - Valencia, Ana
AU  - Fernandez, Agustín F
AU  - Wunderlich, Mark
AU  - Agirre, Xabier
AU  - Prósper, Felipe
AU  - Martín-Subero, José Ignacio
AU  - Maiques, Alba
AU  - Acquadro, Francesco
AU  - Rodriguez Perales, Sandra
AU  - Calasanz, María José
AU  - Roman-Gómez, Jose
AU  - Siebert, Reiner
AU  - Mulloy, James C
AU  - Cervera, José
AU  - Sanz, Miguel Angel
AU  - Esteller, Manel
AU  - Cigudosa, Juan C
PY  - 2010
UR  - https://hdl.handle.net/20.500.12105/26160
AB  - Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemia (AML) pathophysiology. However, further studies to discuss the prognostic value and the relationship of the epigenetic signatures with defined genomic...
AB  - We carried out high-throughput methylation profiling on 116 de novo AML cases and we validated the significant biomarkers in an independent cohort of 244 AML cases. Methylation signatures were associated with the presence of a specific cytogenetic...
AB  - Our study provides a comprehensive epigenetic profiling of AML, identifies new clinical markers for cases with a normal karyotype, and reveals relevant biological information related to the role of fusion proteins on the methylation signature.
LA  - eng
PB  - PUBLIC LIBRARY SCIENCE
KW  - CPG ISLAND METHYLATION
KW  - PREDICTS SURVIVAL
KW  - GENE DBCCR1
KW  - CELLS
KW  - MALIGNANCIES
KW  - CANCER
KW  - EXPRESSION
KW  - DBC1
KW  - EPIGENETICS
KW  - NEOPLASMS
TI  - DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia.
TY  - research article
ER  -