TY  - JOUR
AU  - Sanjuán, Rafael
AU  - Nebot, Miguel R
AU  - Peris, Joan B
AU  - Alcamí, José
PY  - 2013
DO  - 10.1371/journal.pbio.1001523
SN  - 1545-7885
UR  - http://hdl.handle.net/20.500.12105/6932
AB  - The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses....
LA  - eng
PB  - Public Library of Science (PLOS)
KW  - Algorithms
KW  - Amino Acid Sequence
KW  - Conserved Sequence
KW  - Epitopes, T-Lymphocyte
KW  - Evolution, Molecular
KW  - Genetic Variation
KW  - HIV Antigens
KW  - HIV Infections
KW  - HIV-1
KW  - Host-Pathogen Interactions
KW  - Humans
KW  - Immune Evasion
KW  - Immunity, Cellular
KW  - Models, Genetic
KW  - Viral Load
KW  - Virus Replication
KW  - Computer Simulation
TI  - Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1
TY  - journal article
ER  -