TY - GEN AU - Ortega-Molina, Ana AU - Deleyto-Seldas, Nerea AU - Carreras, Joaquim AU - Sanz, Alba AU - Lebrero-Fernández, Cristina AU - Menéndez, Camino AU - Vandenberg, Andrew AU - Fernández-Ruiz, Beatriz AU - Marín-Arraiza, Leyre AU - de la Calle Arregui, Celia AU - Belén Plata-Gómez, Ana AU - Caleiras, Eduardo AU - de Martino, Alba AU - Martínez-Martín, Nuria AU - Troulé, Kevin AU - Piñeiro-Yáñez, Elena AU - Nakamura, Naoya AU - Araf, Shamzah AU - Victora, Gabriel D AU - Okosun, Jessica AU - Fitzgibbon, Jude AU - Efeyan, Alejo PY - 2019 UR - https://hdl.handle.net/20.500.12105/26224 AB - The humoral immune response demands that B cells undergo a sudden anabolic shift and high cellular nutrient levels which are required to sustain the subsequent proliferative burst. Follicular lymphoma (FL) originates from B cells that have... LA - eng PB - Nature Publishing Group KW - B cell lymphoma KW - B lymphocytes KW - RRAGC KW - T follicular helper KW - apoptosis KW - cell growth KW - germinal center KW - mTOR KW - nutrient signaling KW - rapamycin TI - Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR. TY - research article ER -