TY  - JOUR
AU  - The, Inge
AU  - Ruijtenberg, Suzan
AU  - Bouchet, Benjamin P
AU  - Cristobal, Alba
AU  - Prinsen, Martine B W
AU  - van Mourik, Tim
AU  - Koreth, John
AU  - Xu, Huihong
AU  - Heck, Albert J R
AU  - Akhmanova, Anna
AU  - Cuppen, Edwin
AU  - Boxem, Mike
AU  - Muñoz, Javier
AU  - van den Heuvel, Sander
PY  - 2015
DO  - 10.1038/ncomms6906
SN  - 2041-1723
UR  - http://hdl.handle.net/20.500.12105/10005
AB  - Cyclin-dependent kinases 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry. Most human cancers contain overactive CDK4/6-cyclin D, and CDK4/6-specific inhibitors are promising anti-cancer therapeutics. Here, we investigate the...
LA  - eng
PB  - Nature Publishing Group
KW  - Animals
KW  - Base Sequence
KW  - Caenorhabditis elegans
KW  - Caenorhabditis elegans Proteins
KW  - Cdh1 Proteins
KW  - Cell Cycle
KW  - Cell Line, Tumor
KW  - Cyclin D
KW  - Cyclin-Dependent Kinase 4
KW  - Cyclin-Dependent Kinase 6
KW  - Gene Knockdown Techniques
KW  - HEK293 Cells
KW  - Humans
KW  - Immunoprecipitation
KW  - Mass Spectrometry
KW  - Microscopy, Fluorescence
KW  - Molecular Sequence Data
KW  - Multiprotein Complexes
KW  - Repressor Proteins
KW  - Retinoblastoma Protein
KW  - Sequence Analysis, DNA
TI  - Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells
TY  - journal article
ER  -