TY  - JOUR
AU  - Pera, Marta
AU  - Larrea, Delfina
AU  - Guardia-Laguarta, Cristina
AU  - Montesinos, Jorge
AU  - Velasco, Kevin R.
AU  - Agrawal, Rishi R
AU  - Xu, Yimeng
AU  - Chan, Robin B.
AU  - Di Paolo, Gilbert
AU  - Mehler, Mark F.
AU  - Perumal, Geoffrey S.
AU  - Macaluso, Frank P.
AU  - Freyberg, Zachary Z.
AU  - Acin-Perez, Rebeca
AU  - Enriquez, Jose Antonio
AU  - Schon, Eric A.
AU  - Area-Gómez, Estela
PY  - 2017
DO  - 10.15252/embj.201796797
SN  - 0261-4189
UR  - http://hdl.handle.net/20.500.12105/6492
AB  - In the amyloidogenic pathway associated with Alzheimer disease (AD), theamyloid precursor protein (APP) is cleaved by beta-secretase to generatea 99-aa C-terminal fragment (C99) that is then cleaved by c-secretase togenerate the beta-amyloid (Ab)...
LA  - eng
PB  - Wiley
KW  - Alzheimer's disease
KW  - C99
KW  - MAM
KW  - Mitochondria and sphingolipids
KW  - AMYLOID PRECURSOR PROTEIN
KW  - C-TERMINAL FRAGMENT
KW  - BETA-SECRETASE ACTIVITY
KW  - ENDOPLASMIC-RETICULUM
KW  - MOUSE MODEL
KW  - OXIDATIVE STRESS
KW  - TRANSGENIC MICE
KW  - LIPID RAFTS
KW  - A-BETA
KW  - SYNAPTIC MITOCHONDRIA
TI  - Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
TY  - journal article
ER  -