TY - GEN AU - Orrego, Lina M AU - Cabello-Donayre, María AU - Vargas, Paola AU - Martínez-García, Marta AU - Sánchez, Clara AU - Pineda-Molina, Estela AU - Jimenez, Maribel AU - Molina, Ricardo AU - Pérez-Victoria, José M PY - 2019 DO - 10.1096/fj.201901274RR SN - 0892-6638 UR - https://hdl.handle.net/20.500.12105/25500 AB - Heme is an essential molecule synthetized through a broadly conserved 8-step route that has been lost in trypanosomatid parasites. Interestingly, Leishmania reacquired by horizontal gene transfer from γ-proteobacteria the genes coding for the last 3... LA - eng PB - Wiley KW - Ferrochelatase KW - Leishmaniasis KW - Porphyrins KW - Trypanosomatid protozoa KW - Amino Acid Sequence KW - Animals KW - Coproporphyrinogen Oxidase KW - Female KW - Ferrochelatase KW - Heme KW - Leishmania major KW - Leishmaniasis, Cutaneous KW - Macrophages KW - Male KW - Mice KW - Mice, Inbred BALB C KW - Protein Conformation KW - Protoporphyrinogen Oxidase KW - Protozoan Proteins KW - Psychodidae KW - Sequence Homology KW - Virulence TI - Heme synthesis through the life cycle of the heme auxotrophic parasite Leishmania major TY - research article ER -