TY - JOUR AU - Piberger, Ann Liza AU - Bowry, Akhil AU - Kelly, Richard D W AU - Walker, Alexandra K AU - Gonzalez-Acosta, Daniel AU - Bailey, Laura J AU - Doherty, Aidan J AU - Méndez, Juan AU - Morris, Joanna R AU - Bryant, Helen E AU - Petermann, Eva AU - Mendez, Juan PY - 2020 DO - 10.1038/s41467-020-19570-7 UR - http://hdl.handle.net/20.500.12105/12177 AB - Stalled replication forks can be restarted and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle. Bulky DNA adducts are important replication-blocking lesions, but it... LA - eng PB - Nature Publishing Group KW - 4-Nitroquinoline-1-oxide KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - Benz(a)Anthracenes KW - Cell Line KW - DNA Adducts KW - DNA Primase KW - DNA, Single-Stranded KW - DNA-Directed DNA Polymerase KW - Homologous Recombination KW - Humans KW - Multifunctional Enzymes KW - Quinolones KW - Rad51 Recombinase KW - Single Molecule Imaging KW - Sister Chromatid Exchange TI - PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts. TY - journal article ER -