TY  - JOUR
AU  - Gil, Jesús
AU  - Bernard, David
AU  - Martinez Garcia, Maria Dolores
AU  - Beach, David
PY  - 2004
DO  - 10.1038/ncb1077
SN  - 1465-7392
UR  - http://hdl.handle.net/20.500.12105/17404
AB  - In contrast to cancer cells and embryonic stem cells, the lifespan of primary human cells is finite. After a defined number of population doublings, cells enter in an irreversible growth-arrested state termed replicative senescence. Mutations of genes...
LA  - eng
PB  - Nature Publishing Group
KW  - ADP-Ribosylation Factor 1
KW  - Amino Acid Sequence
KW  - Animals
KW  - Base Sequence
KW  - Cell Line, Transformed
KW  - Cell Survival
KW  - Cell Transformation, Neoplastic
KW  - Cellular Senescence
KW  - Cyclin-Dependent Kinase Inhibitor p16
KW  - DNA, Complementary
KW  - Down-Regulation
KW  - Epithelial Cells
KW  - Humans
KW  - Mice
KW  - Molecular Sequence Data
KW  - Nuclear Proteins
KW  - Polycomb Repressive Complex 1
KW  - Polycomb-Group Proteins
KW  - Proto-Oncogene Proteins
KW  - RNA
KW  - Repressor Proteins
KW  - Sequence Homology, Nucleic Acid
TI  - Polycomb CBX7 has a unifying role in cellular lifespan.
TY  - journal article
ER  -