TY - GEN AU - Stewart, Stefan AU - Seco-Meseguer, Enrique AU - Diago-Sempere, Elena AU - Marín-Candón, Alicia AU - Carmona, Montserrat AU - Estébanez, Miriam AU - López-Fernández, Luis A AU - Imaz-Iglesia, Iñaki AU - Del Mar García Saiz, María AU - Laserna-Mendieta, Emilio J AU - Peiró, Ana M AU - Farré, Magí AU - Rodriguez-Jimenez, Consuelo AU - Saiz-Rodriguez, Miriam AU - Sanabria-Cabrera, Judith AU - Rosas-Alonso, Rocío AU - Abad-Santos, Francisco AU - Pedrosa-Pérez, Lucía AU - Carcas, Antonio J AU - García García, Irene AU - Borobia, Alberto M AU - iPHARMGx study group PY - 2024 DO - 10.1136/bmjopen-2024-089823 UR - https://hdl.handle.net/20.500.12105/26625 AB - Introduction: Genetic variations impact drug response, driving the need for personalised medicine through pre-emptive pharmacogenetic testing. However, the adoption of pre-emptive pharmacogenetic testing for commonly prescribed drugs, such as statins,... LA - eng PB - BMJ Publishing Group KW - Clinical-Pharmacology KW - Clinical Trial KW - Genetics KW - Lipid disorders KW - Public health KW - Adaptive Clinical Trials as Topic KW - Cardiovascular Diseases KW - Clinical Trials, Phase IV as Topic KW - Cost-Benefit Analysis KW - Genotype KW - Humans KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Pharmacogenomic Testing KW - Precision Medicine KW - Randomized Controlled Trials as Topic KW - Spain TI - Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHARMGx Master Protocol and PREVESTATGx nested clinical trial TY - research article ER -