TY  - JOUR
AU  - Balaguer, Francisco de Asís
AU  - Mühlethaler, Tobias
AU  - Estévez-Gallego, Juan
AU  - Calvo, Enrique
AU  - Giménez-Abián, Juan Francisco
AU  - Risinger, April L
AU  - Sorensen, Erik J
AU  - Vanderwal, Christopher D
AU  - Altmann, Karl-Heinz
AU  - Mooberry, Susan L
AU  - Steinmetz, Michel O
AU  - Oliva, María Ángela
AU  - Prota, Andrea E
AU  - Díaz, J Fernando
PY  - 2019
DO  - 10.3390/ijms20061392
SN  - 1422-0067
UR  - http://hdl.handle.net/20.500.12105/7516
AB  - It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded helical structure in microtubules....
LA  - eng
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
KW  - Cyclostreptin
KW  - Microtubules
KW  - Multidrug resistance
KW  - Taxanes
KW  - Tubulin
TI  - Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands
TY  - journal article
ER  -