TY  - JOUR
AU  - Acin-Perez, Rebeca
AU  - Iborra, Salvador
AU  - Martí-Mateos, Yolanda
AU  - Cook, Emma CL
AU  - Conde-Garrosa, Ruth
AU  - Petcherski, Anton
AU  - Muñoz, Mª Del Mar
AU  - Martínez de Mena, Raquel
AU  - Krishnan, Karthickeyan Chella
AU  - Jiménez, Concepción
AU  - Bolaños, Juan Pedro
AU  - Laakso, Markku
AU  - Lusis, Aldon J
AU  - Shirihai, Orian S
AU  - Sancho, David
AU  - Enriquez, Jose Antonio
PY  - 2020
DO  - 10.1038/s42255-020-00273-8
UR  - http://hdl.handle.net/20.500.12105/14683
AB  - Proinflammatory macrophages are key in the development of obesity. In addition, reactive oxygen species (ROS), which activate the Fgr tyrosine kinase, also contribute to obesity. Here we show that ablation of Fgr impairs proinflammatory macrophage...
LA  - eng
KW  - Diet, High-Fat
KW  - Macrophage Activation
KW  - Adipose Tissue, White
KW  - Animals
KW  - Bone Marrow Cells
KW  - Fatty Liver
KW  - Inflammation
KW  - Insulin Resistance
KW  - Interleukin-1beta
KW  - Magnetic Resonance Imaging
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mitochondria, Liver
KW  - Obesity
KW  - Proto-Oncogene Proteins
KW  - Reactive Oxygen Species
KW  - src-Family Kinases
TI  - Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity.
TY  - journal article
ER  -