TY - GEN AU - Vida, Margarita AU - Gavito, Ana Luisa AU - Pavón, Francisco-Javier AU - Bautista, Dolores AU - Serrano, Antonia AU - Suarez, Juan AU - Arrabal, Sergio AU - Decara, Juan AU - Romero-Cuevas, Miguel AU - Rodríguez De Fonseca, Fernando AU - Baixeras, Elena PY - 2015 DO - 10.1242/dmm.019166 SN - 1754-8403 UR - http://hdl.handle.net/20.500.12105/18878 AB - Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid metabolism with paradoxical effects in the liver. Administration of IL-6 has been reported to confer protection against steatosis, but plasma and tissue IL-6 concentrations are... LA - eng PB - The Company of Biologists KW - Interleukin-6 KW - Liver KW - Lipogenesis KW - Steatosis KW - Acetyl-CoA Carboxylase KW - Animals KW - Carnitine O-Palmitoyltransferase KW - Cytokinesis KW - Diet, High-Fat KW - Disease Models, Animal KW - Hep G2 Cells KW - Humans KW - Interleukin-6 KW - Lipogenesis KW - Liver KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Phosphorylation KW - Recombinant Proteins KW - STAT3 Transcription Factor KW - Stearoyl-CoA Desaturase KW - Suppressor of Cytokine Signaling Proteins KW - AMP-Activated Protein Kinases KW - Fatty Acid Synthase, Type I KW - Non-alcoholic Fatty Liver Disease TI - Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice TY - research article ER -