TY  - GEN
AU  - Hernández-Porras, Isabel
AU  - Fabbiano, Salvatore
AU  - Schuhmacher, Alberto J
AU  - Aicher, Alexandra
AU  - Cañamero, Marta
AU  - Cámara, Juan Antonio
AU  - Cussó, Lorena
AU  - Desco, Manuel
AU  - Heeschen, Christopher
AU  - Mulero, Francisca
AU  - Bustelo, Xosé R
AU  - Guerra, Carmen
AU  - Barbacid, Mariano
PY  - 2014
DO  - 10.1073/pnas.1418126111
UR  - https://hdl.handle.net/20.500.12105/23066
AB  - Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, craniofacial dysmorphism, and congenital heart defects. NS also is associated with a risk for developing myeloproliferative disorders (MPD), including...
LA  - eng
PB  - National Academy of Sciences
KW  - Disease Models, Animal
KW  - Genes, ras
KW  - Mice, Mutant Strains
KW  - Mutation, Missense
KW  - Point Mutation
KW  - Abnormalities, Multiple
KW  - Alleles
KW  - Amino Acid Substitution
KW  - Animals
KW  - Body Size
KW  - Cell Lineage
KW  - Crosses, Genetic
KW  - Dwarfism
KW  - Epistasis, Genetic
KW  - Face
KW  - Female
KW  - Genes, Dominant
KW  - Genotype
KW  - Heart Defects, Congenital
KW  - Hematopoiesis
KW  - Leukemia, Myelomonocytic, Juvenile
KW  - MAP Kinase Kinase Kinases
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Myeloproliferative Disorders
KW  - Neoplastic Syndromes, Hereditary
KW  - Noonan Syndrome
KW  - Phenotype
KW  - Pregnancy
KW  - Prenatal Exposure Delayed Effects
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Radiation Chimera
KW  - Signal Transduction
TI  - K-RasV14I recapitulates Noonan syndrome in mice.
TY  - research article
ER  -