TY - GEN AU - Lázaro-Gorines, Rodrigo AU - López-Rodríguez, Juan Carlos AU - Benedé, Sara AU - González, Miguel AU - Mayorga, Cristobalina AU - Vogel, Lothar AU - Martínez-Del-Pozo, Álvaro AU - Lacadena, Javier AU - Villalba, Mayte PY - 2020 DO - 10.1038/s41598-020-69166-w UR - http://hdl.handle.net/20.500.12105/18081 AB - Immunotoxins appear as promising therapeutic molecules, alternative to allergen-specific-immunotherapy. In this work, we achieved the development of a protein chimera able to promote specific cell death on effector cells involved in the allergic... LA - eng PB - Springer KW - Allergy KW - Der p 1 KW - Immunotoxins KW - Basophils KW - Cell death KW - Pyroglyphidae KW - Hipersensibilidad KW - Inmunotoxinas KW - Basófilos KW - Muerte celular KW - Allergens KW - Animals KW - Antigens, Dermatophagoides KW - Arthropod Proteins KW - Basophils KW - Cell Degranulation KW - Cell Line KW - Cells, Cultured KW - Cysteine Endopeptidases KW - Dermatophagoides pteronyssinus KW - Desensitization, Immunologic KW - Humans KW - Hypersensitivity KW - Immunoglobulin E KW - Immunotoxins KW - Recombinant Proteins KW - Cell Degranulation KW - Cell Death TI - Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy TY - research article ER -