TY - JOUR AU - De Majo, Federica AU - Martens, Leonie AU - Hegenbarth, Jana-Charlotte AU - Rühle, Frank AU - Hamczyk, Magda R AU - Nevado, Rosa M AU - Andres, Vicente AU - Hilbold, Erika AU - Bär, Christian AU - Thum, Thomas AU - de Boer, Martine AU - Duncker, Dirk J AU - Schroen, Blanche AU - Armand, Anne-Sophie AU - Stoll, Monika AU - De Windt, Leon J PY - 2021 DO - 10.1073/pnas.2022974118 UR - http://hdl.handle.net/20.500.12105/15198 AB - Genomic instability, the unresolved accumulation of DNA variants, is hypothesized as one of the contributors to the natural aging process. We assessed the frequency of unresolved DNA damage reaching the transcriptome of the murine myocardium during... LA - eng PB - National Academy of Sciences KW - Aging KW - Aging, Premature KW - Animals KW - Cellular Senescence KW - DNA Damage KW - DNA Repair KW - DNA-Binding Proteins KW - Disease Models, Animal KW - Endonucleases KW - Female KW - Genomic Instability KW - Heart KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mitochondria KW - Myocardium TI - Genomic instability in the naturally and prematurely aged myocardium. TY - journal article ER -