TY  - GEN
AU  - Palacios, José
AU  - Honrado, Emiliano
AU  - Osorio, Ana
AU  - Cazorla, Alicia
AU  - Sarrió, David
AU  - Barroso, Alicia
AU  - Rodriguez Perales, Sandra
AU  - Cigudosa, Juan C
AU  - Diez, Orland
AU  - Alonso, Carmen
AU  - Lerma, Enrique
AU  - Sánchez, Lydia
AU  - Rivas, Carmen
AU  - Benítez, Javier
PY  - 2003
UR  - https://hdl.handle.net/20.500.12105/26167
AB  - Most familial breast cancers are not associated with BRCA1 or BRCA2 germ-line mutations. Therefore, it is of major importance to define the morphological, immunohistochemical, and molecular features of this group of tumors to improve genetic testing...
AB  - We evaluated the morphological characteristics of 37 tumors arising in women without BRCA1 or BRCA2 mutations, 20 tumors from BRCA1 mutation carriers, and 18 from BRCA2 mutation carriers, all of which were from index patients from breast cancer...
AB  - Non-BRCA1/2 infiltrating ductal carcinomas (IDCs) showed specific differences from BRCA1 tumors. They were of lower grade (1 and 2); more frequently estrogen receptor, progesterone receptor, BCL2 positive, and p53 negative; had a low proliferation...
AB  - This study thus reveals distinct morphological and immunohistochemical features in non-BRCA1/2 and BRCA1 tumors, whereas BRCA2 tumors present characteristics intermediate between the two phenotypes. In addition, the study also demonstrates the...
LA  - eng
PB  - AMER ASSOC CANCER RESEARCH
TI  - Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.
TY  - research article
ER  -