TY  - JOUR
AU  - Quintana-Bustamante, Oscar
AU  - Fañanas-Baquero, Sara
AU  - Orman, Israel
AU  - Torres-Ruiz Raul, Raul
AU  - Duchateau, Philippe
AU  - Poirot, Laurent
AU  - Gouble, Agnès
AU  - Bueren, Juan A
AU  - Segovia, Jose Carlos
PY  - 2019
DO  - 10.1371/journal.pone.0223775
SN  - 1932-6203
UR  - http://hdl.handle.net/20.500.12105/9354
AB  - Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme. Erythrocytes from PKD patients show an energetic imbalance and are susceptible to...
LA  - eng
PB  - BioMed Central (BMC)
KW  - 3' Untranslated Regions
KW  - 5' Untranslated Regions
KW  - Animals
KW  - Cells, Cultured
KW  - Gene Editing
KW  - HEK293 Cells
KW  - Hematopoietic Stem Cells
KW  - Humans
KW  - Mice
KW  - Pyruvate Kinase
KW  - Transcription Activator-Like Effector Nucleases
TI  - Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA
TY  - journal article
ER  -