TY  - GEN
AU  - Garcia, Maria Teresa
AU  - Blázquez, María Amparo
AU  - Ferrandiz-Avellano, Maria-Jose
AU  - Sanz, María Jesús
AU  - Silva-Martín, Noella
AU  - Hermoso, Juan A
AU  - de la Campa, Adela G
PY  - 2011
DO  - 10.1074/jbc.M110.148148
SN  - 0021-9258
UR  - http://hdl.handle.net/20.500.12105/8593
AB  - Streptococcus pneumoniae has two type II DNA-topoisomerases (DNA-gyrase and DNA topoisomerase IV) and a single type I enzyme (DNA-topoisomerase I, TopA), as demonstrated here. Although fluoroquinolones target type II enzymes, antibiotics efficiently...
LA  - eng
PB  - American Society for Biochemistry and Molecular Biology (ASBMB)
KW  - Bacterial Proteins
KW  - Cell Line
KW  - DNA Topoisomerases, Type I
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Models, Molecular
KW  - Protein Structure, Tertiary
KW  - Streptococcus pneumoniae
KW  - Alkaloids
KW  - Anti-Bacterial Agents
KW  - Phenanthrenes
KW  - Topoisomerase I Inhibitors
TI  - New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae
TY  - research article
ER  -