TY  - JOUR
AU  - Morgado-Palacin, Isabel
AU  - Day, Amanda
AU  - Murga, Matilde
AU  - Lafarga, Vanesa
AU  - Anton, Marta Elena
AU  - Tubbs, Anthony
AU  - Chen, Hua Tang
AU  - Ergan, Aysegul
AU  - Anderson, Rhonda
AU  - Bhandoola, Avinash
AU  - Pike, Kurt G
AU  - Barlaam, Bernard
AU  - Cadogan, Elaine
AU  - Wang, Xi
AU  - Pierce, Andrew J
AU  - Hubbard, Chad
AU  - Armstrong, Scott A
AU  - Nussenzweig, André
AU  - Fernandez-Capetillo, Oscar
PY  - 2016
DO  - 10.1126/scisignal.aad8243
UR  - http://hdl.handle.net/20.500.12105/17690
AB  - Among the various subtypes of acute myeloid leukemia (AML), those with chromosomal rearrangements of the MLL oncogene (AML-MLL) have a poor prognosis. AML-MLL tumor cells are resistant to current genotoxic therapies because of an attenuated response...
LA  - eng
PB  - American Association for the Advancement of Science (AAAS)
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - Gene Rearrangement
KW  - Histone-Lysine N-Methyltransferase
KW  - Leukemia, Myeloid, Acute
KW  - Myeloid-Lymphoid Leukemia Protein
KW  - Neoplasms, Experimental
KW  - Animals
KW  - Humans
KW  - Mice
KW  - Xenograft Model Antitumor Assays
TI  - Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.
TY  - journal article
ER  -