TY - JOUR AU - Cuevas-Navarro, Antonio AU - Rodriguez-Muñoz, Laura AU - Grego-Bessa, Joaquim AU - Cheng, Alice AU - Rauen, Katherine A AU - Urisman, Anatoly AU - McCormick, Frank AU - Jimenez, Gerardo AU - Castel, Pau PY - 2022 DO - 10.7554/eLife.76495 UR - http://hdl.handle.net/20.500.12105/15739 AB - RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds, ubiquitinates, and... LA - eng PB - eLife Sciences Publications KW - Adaptor Proteins, Signal Transducing KW - Drosophila Proteins KW - Transcription Factors KW - ras Proteins KW - Animals KW - Cell Proliferation KW - Mice KW - Signal Transduction KW - Ubiquitination TI - Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs. TY - journal article ER -