TY  - GEN
AU  - Torices, Silvia
AU  - Julia, Antonio
AU  - Muñoz, Pedro
AU  - Varela, Ignacio
AU  - Balsa, Alejandro
AU  - Marsal, Sara
AU  - Fernández-Nebro, Antonio
AU  - Blanco, Francisco
AU  - Lopez-Hoyos, Marcos
AU  - Martinez-Taboada, Víctor
AU  - Fernández-Luna, Jose L
PY  - 2016
DO  - 10.1186/s13075-016-1113-z
UR  - http://hdl.handle.net/20.500.12105/17160
AB  - Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is as yet unknown. We aimed at identifying TLR10 variants...
LA  - eng
KW  - Infliximab
KW  - NFkB
KW  - Rheumatoid arthritis
KW  - TLR10 variant
KW  - Aged
KW  - Antirheumatic Agents
KW  - Arthritis, Rheumatoid
KW  - Drug Resistance
KW  - Female
KW  - Gene Expression Regulation
KW  - Genotype
KW  - High-Throughput Nucleotide Sequencing
KW  - Humans
KW  - Infliximab
KW  - Male
KW  - Middle Aged
KW  - NF-kappa B
KW  - Polymorphism, Single Nucleotide
KW  - Prognosis
KW  - Real-Time Polymerase Chain Reaction
KW  - Toll-Like Receptor 10
TI  - A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis.
TY  - research article
ER  -