TY  - GEN
AU  - Flydal, Marte Innselset
AU  - Alcorlo-Pagés, Martín
AU  - Johannessen, Fredrik Gullaksen
AU  - Martínez-Caballero, Siseth
AU  - Skjærven, Lars
AU  - Fernandez-Leiro, Rafael
AU  - Martinez, Aurora
AU  - Hermoso, Juan A
AU  - Flydal, Marte Innselset
AU  - Alcorlo-Pagés, Martín
AU  - Johannessen, Fredrik Gullaksen
AU  - Martínez-Caballero, Siseth
AU  - Skjærven, Lars
AU  - Fernandez-Leiro, Rafael
AU  - Martinez, Aurora
AU  - Hermoso, Juan A
PY  - 2019
UR  - https://hdl.handle.net/20.500.12105/23566
AB  - Phenylalanine hydroxylase (PAH) is a key enzyme in the catabolism of phenylalanine, and mutations in this enzyme cause phenylketonuria (PKU), a genetic disorder that leads to brain damage and mental retardation if untreated. Some patients benefit from...
LA  - eng
PB  - National Academy of Sciences
KW  - X-ray crystallography
KW  - allosteric regulation
KW  - cryo-EM
KW  - human phenylalanine hydroxylase
KW  - phenylketonuria
TI  - Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin.
TY  - research article
ER  -